Drug interactions
Fostamatinib + Pazopanib
Severity: Moderate
Fostamatinib and Pazopanib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fostamatinib's active metabolite R406 inhibits P-gp and BCRP, transporters that handle pazopanib. Pazopanib exposure may rise, increasing the risk of adverse effects such as hepatotoxicity, hypertension and diarrhea.
What this interaction means in plain words
Fostamatinib and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fostamatinib belongs to Oncology; Pazopanib belongs to Oncology.
Why it happens
R406 inhibits intestinal P-gp and BCRP efflux, increasing pazopanib absorption and exposure.
What to do
Monitor liver function tests and blood pressure, and reduce the pazopanib dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Other interactions of Fostamatinib
- Colchicine + Fostamatinib Major
- Fostamatinib + Phenytoin Major
- Amobarbital + Fostamatinib Moderate
- Apalutamide + Fostamatinib Moderate
- Atorvastatin + Fostamatinib Moderate
- Bosentan + Fostamatinib Moderate
Frequently asked questions
Can I take Fostamatinib with Pazopanib?
MediHelp rates the interaction as moderate. Fostamatinib and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fostamatinib's active metabolite R406 inhibits P-gp and BCRP, transporters that handle pazopanib. Pazopanib exposure may rise, increasing the risk of adverse effects such as hepatotoxicity, hypertension and diarrhea.
How serious is the interaction between Fostamatinib and Pazopanib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver function tests and blood pressure, and reduce the pazopanib dose if toxicity develops.
What other medicines interact with Pazopanib?
MediHelp also lists interactions of Pazopanib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pazopanib page.
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