Drug interactions
Fostamatinib + Topotecan
Severity: Moderate
Fostamatinib and Topotecan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fostamatinib's active metabolite inhibits BCRP and P-gp and may raise topotecan concentrations, increasing the risk of myelosuppression.
What this interaction means in plain words
Fostamatinib and Topotecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fostamatinib belongs to Oncology; Topotecan belongs to Oncology.
Why it happens
Fostamatinib's active metabolite inhibits BCRP and P-gp efflux of topotecan.
What to do
Monitor blood counts and for topotecan toxicity. Reduce the topotecan dose if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Topotecan
- Adenovirus types 4 and 7 live + Topotecan Contraindicated
- Amiodarone + Topotecan Major
- Cisplatin + Topotecan Major
- Cobicistat + Topotecan Major
- Cyclosporin + Topotecan Major
- Darunavir + Topotecan Major
Other interactions of Fostamatinib
- Colchicine + Fostamatinib Major
- Fostamatinib + Phenytoin Major
- Amobarbital + Fostamatinib Moderate
- Apalutamide + Fostamatinib Moderate
- Atorvastatin + Fostamatinib Moderate
- Bosentan + Fostamatinib Moderate
Frequently asked questions
Can I take Fostamatinib with Topotecan?
MediHelp rates the interaction as moderate. Fostamatinib and Topotecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fostamatinib's active metabolite inhibits BCRP and P-gp and may raise topotecan concentrations, increasing the risk of myelosuppression.
How serious is the interaction between Fostamatinib and Topotecan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and for topotecan toxicity. Reduce the topotecan dose if toxicity occurs.
What other medicines interact with Topotecan?
MediHelp also lists interactions of Topotecan with, for example, Adenovirus types 4 and 7 live, Amiodarone, Cisplatin. The full list is on the Topotecan page.
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