Drug interactions
Fostemsavir + Granisetron
Severity: Moderate
Fostemsavir and Granisetron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fostemsavir has been associated with QTc prolongation at supratherapeutic doses, and granisetron can prolong QT modestly. The combination may add to arrhythmia risk, mainly in patients with other risk factors.
What this interaction means in plain words
Fostemsavir and Granisetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fostemsavir belongs to Anti Virals; Granisetron belongs to Gastrointestinal Tract.
Why it happens
Additive QT interval prolongation.
What to do
Use an ECG and check electrolytes in patients with cardiac disease, electrolyte disturbances or other QT-prolonging drugs. Correct hypokalemia and hypomagnesemia first.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Granisetron
- Apomorphine + Granisetron Contraindicated
- Amiodarone + Granisetron Major
- Amisulpride + Granisetron Major
- Arsenic trioxide + Granisetron Major
- Artemether / lumefantrine + Granisetron Major
- Artemether + Granisetron Major
Other interactions of Fostemsavir
- Apalutamide + Fostemsavir Contraindicated
- Carbamazepine + Fostemsavir Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Fostemsavir + Phenytoin Contraindicated
- Fostemsavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Fostemsavir with Granisetron?
MediHelp rates the interaction as moderate. Fostemsavir and Granisetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fostemsavir has been associated with QTc prolongation at supratherapeutic doses, and granisetron can prolong QT modestly. The combination may add to arrhythmia risk, mainly in patients with other risk factors.
How serious is the interaction between Fostemsavir and Granisetron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an ECG and check electrolytes in patients with cardiac disease, electrolyte disturbances or other QT-prolonging drugs. Correct hypokalemia and hypomagnesemia first.
What other medicines interact with Granisetron?
MediHelp also lists interactions of Granisetron with, for example, Apomorphine, Amiodarone, Amisulpride. The full list is on the Granisetron page.
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