Drug interactions
Fostemsavir + Hydroxyzine
Severity: Moderate
Fostemsavir and Hydroxyzine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydroxyzine can prolong the QT interval, and fostemsavir has been associated with QTc prolongation at supratherapeutic doses. Combined use may add to the risk of torsades de pointes, particularly with other risk factors.
What this interaction means in plain words
Fostemsavir and Hydroxyzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fostemsavir belongs to Anti Virals; Hydroxyzine belongs to Respiratory.
Why it happens
Additive effects on cardiac repolarization (hERG potassium channel blockade).
What to do
Obtain a baseline ECG and correct potassium and magnesium before combining. Avoid exceeding the recommended fostemsavir dose and monitor the ECG in patients with other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Other interactions of Fostemsavir
- Apalutamide + Fostemsavir Contraindicated
- Carbamazepine + Fostemsavir Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Fostemsavir + Phenytoin Contraindicated
- Fostemsavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Fostemsavir with Hydroxyzine?
MediHelp rates the interaction as moderate. Fostemsavir and Hydroxyzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydroxyzine can prolong the QT interval, and fostemsavir has been associated with QTc prolongation at supratherapeutic doses. Combined use may add to the risk of torsades de pointes, particularly with other risk factors.
How serious is the interaction between Fostemsavir and Hydroxyzine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium before combining. Avoid exceeding the recommended fostemsavir dose and monitor the ECG in patients with other QT risk factors.
What other medicines interact with Hydroxyzine?
MediHelp also lists interactions of Hydroxyzine with, for example, Droperidol, Pimozide, Thioridazine. The full list is on the Hydroxyzine page.
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