Drug interactions
Fostemsavir + Lovastatin
Severity: Moderate
Fostemsavir and Lovastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fostemsavir's active metabolite inhibits hepatic uptake transporters OATP1B1 and OATP1B3, which may raise systemic exposure to statins that depend on these transporters. Lovastatin acid is an OATP substrate, so higher levels could increase the risk of myopathy.
What this interaction means in plain words
Fostemsavir and Lovastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fostemsavir belongs to Anti Virals; Lovastatin belongs to Cardiovascular.
Why it happens
Inhibition of OATP1B1/1B3-mediated hepatic uptake of lovastatin acid reduces its hepatic clearance.
What to do
Use the lowest effective lovastatin dose and monitor for muscle pain, weakness or elevated CK. Consider a statin less dependent on OATP transport if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lovastatin
- Atazanavir + Lovastatin Contraindicated
- Clarithromycin + Lovastatin Contraindicated
- Cobicistat + Lovastatin Contraindicated
- Conivaptan + Lovastatin Contraindicated
- Darunavir + Lovastatin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Lovastatin Contraindicated
Other interactions of Fostemsavir
- Apalutamide + Fostemsavir Contraindicated
- Carbamazepine + Fostemsavir Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Fostemsavir + Phenytoin Contraindicated
- Fostemsavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Fostemsavir with Lovastatin?
MediHelp rates the interaction as moderate. Fostemsavir and Lovastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fostemsavir's active metabolite inhibits hepatic uptake transporters OATP1B1 and OATP1B3, which may raise systemic exposure to statins that depend on these transporters. Lovastatin acid is an OATP substrate, so higher levels could increase the risk of myopathy.
How serious is the interaction between Fostemsavir and Lovastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective lovastatin dose and monitor for muscle pain, weakness or elevated CK. Consider a statin less dependent on OATP transport if symptoms develop.
What other medicines interact with Lovastatin?
MediHelp also lists interactions of Lovastatin with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Lovastatin page.
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