Drug interactions
Fostemsavir + Paliperidone
Severity: Moderate
Fostemsavir and Paliperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paliperidone can prolong the QT interval, and fostemsavir has been associated with QT prolongation at supratherapeutic doses. Together they may add to the risk of ventricular arrhythmia, particularly with other risk factors.
What this interaction means in plain words
Fostemsavir and Paliperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fostemsavir belongs to Anti Virals; Paliperidone belongs to Central Nervous System.
Why it happens
Additive effects on cardiac repolarization through hERG potassium channel blockade.
What to do
Obtain a baseline ECG and correct hypokalemia and hypomagnesemia. Keep fostemsavir at the recommended dose and monitor the ECG in patients with other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paliperidone
- Ibutilide + Paliperidone Contraindicated
- Paliperidone + Pimozide Contraindicated
- Paliperidone + Vandetanib Contraindicated
- Adagrasib + Paliperidone Major
- Amiodarone + Paliperidone Major
- Amisulpride + Paliperidone Major
Other interactions of Fostemsavir
- Apalutamide + Fostemsavir Contraindicated
- Carbamazepine + Fostemsavir Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Fostemsavir + Phenytoin Contraindicated
- Fostemsavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Fostemsavir with Paliperidone?
MediHelp rates the interaction as moderate. Fostemsavir and Paliperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Paliperidone can prolong the QT interval, and fostemsavir has been associated with QT prolongation at supratherapeutic doses. Together they may add to the risk of ventricular arrhythmia, particularly with other risk factors.
How serious is the interaction between Fostemsavir and Paliperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct hypokalemia and hypomagnesemia. Keep fostemsavir at the recommended dose and monitor the ECG in patients with other QT risk factors.
What other medicines interact with Paliperidone?
MediHelp also lists interactions of Paliperidone with, for example, Ibutilide, Pimozide, Vandetanib. The full list is on the Paliperidone page.
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