Drug interactions
Fostemsavir + Solifenacin
Severity: Moderate
Fostemsavir and Solifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fostemsavir has caused QT prolongation at supratherapeutic doses, and solifenacin can also prolong the QT interval. At recommended doses the additive risk is modest but matters in patients with other risk factors.
What this interaction means in plain words
Fostemsavir and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fostemsavir belongs to Anti Virals; Solifenacin belongs to Genitourinary.
Why it happens
Additive QT interval prolongation.
What to do
Obtain an ECG and correct electrolyte disturbances in patients with cardiac risk factors or other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Solifenacin
Other interactions of Fostemsavir
- Apalutamide + Fostemsavir Contraindicated
- Carbamazepine + Fostemsavir Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Fostemsavir + Phenytoin Contraindicated
- Fostemsavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Fostemsavir with Solifenacin?
MediHelp rates the interaction as moderate. Fostemsavir and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fostemsavir has caused QT prolongation at supratherapeutic doses, and solifenacin can also prolong the QT interval. At recommended doses the additive risk is modest but matters in patients with other risk factors.
How serious is the interaction between Fostemsavir and Solifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG and correct electrolyte disturbances in patients with cardiac risk factors or other QT-prolonging drugs.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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