Drug interactions
Frovatriptan + Gepirone
Severity: Moderate
Frovatriptan and Gepirone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gepirone is a 5-HT1A agonist antidepressant and frovatriptan is a 5-HT1B/1D agonist. Together they could increase serotonergic activity and risk of serotonin syndrome.
What this interaction means in plain words
Frovatriptan and Gepirone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Frovatriptan belongs to Central Nervous System; Gepirone belongs to Central Nervous System.
Why it happens
Additive serotonergic receptor stimulation.
What to do
Monitor for symptoms of serotonin syndrome, especially when starting or increasing doses. Discontinue the offending drug and provide supportive care if it occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Frovatriptan
- Almotriptan + Frovatriptan Contraindicated
- Dihydroergotamine intranasal + Frovatriptan Contraindicated
- Dihydroergotamine + Frovatriptan Contraindicated
- Eletriptan + Frovatriptan Contraindicated
- Ergoloid mesylates + Frovatriptan Contraindicated
- Ergotamine + Frovatriptan Contraindicated
Other interactions of Gepirone
- Clarithromycin + Gepirone Contraindicated
- Gepirone + Isocarboxazid Contraindicated
- Gepirone + Itraconazole Contraindicated
- Gepirone + Ketoconazole Contraindicated
- Gepirone + Linezolid Contraindicated
- Gepirone + Phenelzine Contraindicated
Frequently asked questions
Can I take Frovatriptan with Gepirone?
MediHelp rates the interaction as moderate. Frovatriptan and Gepirone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gepirone is a 5-HT1A agonist antidepressant and frovatriptan is a 5-HT1B/1D agonist. Together they could increase serotonergic activity and risk of serotonin syndrome.
How serious is the interaction between Frovatriptan and Gepirone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for symptoms of serotonin syndrome, especially when starting or increasing doses. Discontinue the offending drug and provide supportive care if it occurs.
What other medicines interact with Frovatriptan?
MediHelp also lists interactions of Frovatriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Frovatriptan page.
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