Drug interactions
Frovatriptan + Mirtazapine
Severity: Moderate
Frovatriptan and Mirtazapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents act on serotonergic pathways, so combined use could in theory contribute to serotonin syndrome. Reported cases with triptans and antidepressants are uncommon, and the risk is considered low.
What this interaction means in plain words
Frovatriptan and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Frovatriptan belongs to Central Nervous System; Mirtazapine belongs to Central Nervous System.
Why it happens
Additive serotonergic activity: mirtazapine antagonizes 5-HT2/5-HT3 receptors and enhances serotonin release, while frovatriptan is a 5-HT1B/1D agonist.
What to do
Counsel the patient to report agitation, tremor, sweating, diarrhea or hyperthermia after a triptan dose. Stop the triptan and treat if serotonin syndrome is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Other interactions of Frovatriptan
- Almotriptan + Frovatriptan Contraindicated
- Dihydroergotamine intranasal + Frovatriptan Contraindicated
- Dihydroergotamine + Frovatriptan Contraindicated
- Eletriptan + Frovatriptan Contraindicated
- Ergoloid mesylates + Frovatriptan Contraindicated
- Ergotamine + Frovatriptan Contraindicated
Frequently asked questions
Can I take Frovatriptan with Mirtazapine?
MediHelp rates the interaction as moderate. Frovatriptan and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents act on serotonergic pathways, so combined use could in theory contribute to serotonin syndrome. Reported cases with triptans and antidepressants are uncommon, and the risk is considered low.
How serious is the interaction between Frovatriptan and Mirtazapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient to report agitation, tremor, sweating, diarrhea or hyperthermia after a triptan dose. Stop the triptan and treat if serotonin syndrome is suspected.
What other medicines interact with Mirtazapine?
MediHelp also lists interactions of Mirtazapine with, for example, Isocarboxazid, Phenelzine, Pimozide. The full list is on the Mirtazapine page.
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