Drug interactions
Frovatriptan + Ondansetron
Severity: Moderate
Frovatriptan and Ondansetron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have serotonergic activity, and serotonin syndrome has been reported with 5-HT3 antagonists combined with triptans. The risk appears low in practice, and the combination is commonly used for migraine-related nausea.
What this interaction means in plain words
Frovatriptan and Ondansetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Frovatriptan belongs to Central Nervous System; Ondansetron belongs to Gastrointestinal Tract.
Why it happens
Additive serotonergic effects, though 5-HT3 antagonism is not a firmly established cause of serotonin toxicity.
What to do
The combination can be used with awareness; counsel patients to report agitation, tremor, sweating, diarrhea or fever. Stop both drugs if serotonin syndrome is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ondansetron
- Apomorphine + Ondansetron Contraindicated
- Ondansetron + Thioridazine Contraindicated
- Ondansetron + Vandetanib Contraindicated
- Adagrasib + Ondansetron Major
- Amiodarone + Ondansetron Major
- Amisulpride + Ondansetron Major
Other interactions of Frovatriptan
- Almotriptan + Frovatriptan Contraindicated
- Dihydroergotamine intranasal + Frovatriptan Contraindicated
- Dihydroergotamine + Frovatriptan Contraindicated
- Eletriptan + Frovatriptan Contraindicated
- Ergoloid mesylates + Frovatriptan Contraindicated
- Ergotamine + Frovatriptan Contraindicated
Frequently asked questions
Can I take Frovatriptan with Ondansetron?
MediHelp rates the interaction as moderate. Frovatriptan and Ondansetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have serotonergic activity, and serotonin syndrome has been reported with 5-HT3 antagonists combined with triptans. The risk appears low in practice, and the combination is commonly used for migraine-related nausea.
How serious is the interaction between Frovatriptan and Ondansetron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: The combination can be used with awareness; counsel patients to report agitation, tremor, sweating, diarrhea or fever. Stop both drugs if serotonin syndrome is suspected.
What other medicines interact with Ondansetron?
MediHelp also lists interactions of Ondansetron with, for example, Apomorphine, Thioridazine, Vandetanib. The full list is on the Ondansetron page.
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