Drug interactions
Frovatriptan + Ozanimod
Severity: Moderate
Frovatriptan and Ozanimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ozanimod's active metabolite inhibits MAO-B in vitro, and its combination with serotonergic or sympathomimetic drugs may cause serious reactions such as hypertensive crisis or serotonin syndrome. Frovatriptan is mainly cleared by CYP1A2, so the real risk is likely modest but uncertain.
What this interaction means in plain words
Frovatriptan and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Frovatriptan belongs to Central Nervous System; Ozanimod belongs to Central Nervous System.
Why it happens
Possible MAO inhibition by ozanimod metabolites may increase monoamine and triptan effects.
What to do
Monitor blood pressure and watch for serotonin toxicity symptoms when combining. Consider an alternative acute migraine therapy if hypertension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Frovatriptan
- Almotriptan + Frovatriptan Contraindicated
- Dihydroergotamine intranasal + Frovatriptan Contraindicated
- Dihydroergotamine + Frovatriptan Contraindicated
- Eletriptan + Frovatriptan Contraindicated
- Ergoloid mesylates + Frovatriptan Contraindicated
- Ergotamine + Frovatriptan Contraindicated
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Frovatriptan with Ozanimod?
MediHelp rates the interaction as moderate. Frovatriptan and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ozanimod's active metabolite inhibits MAO-B in vitro, and its combination with serotonergic or sympathomimetic drugs may cause serious reactions such as hypertensive crisis or serotonin syndrome. Frovatriptan is mainly cleared by CYP1A2, so the real risk is likely modest but uncertain.
How serious is the interaction between Frovatriptan and Ozanimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and watch for serotonin toxicity symptoms when combining. Consider an alternative acute migraine therapy if hypertension develops.
What other medicines interact with Frovatriptan?
MediHelp also lists interactions of Frovatriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Frovatriptan page.
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