Drug interactions
Frovatriptan + Zileuton
Severity: Minor
Frovatriptan and Zileuton: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Frovatriptan is partly cleared by CYP1A2, so zileuton may modestly raise its concentrations. Clinical significance is likely small given the drug's wide tolerability.
What this interaction means in plain words
Frovatriptan and Zileuton have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Frovatriptan belongs to Central Nervous System; Zileuton belongs to Respiratory.
Why it happens
Zileuton inhibits CYP1A2, reducing frovatriptan metabolism.
What to do
No dose adjustment is usually needed. Watch for triptan adverse effects such as dizziness, chest tightness or blood pressure rise.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Zileuton
- Fezolinetant + Zileuton Contraindicated
- Pimozide + Zileuton Contraindicated
- Alosetron + Zileuton Major
- Clozapine + Zileuton Major
- Lomitapide + Zileuton Major
- Lonafarnib + Zileuton Major
Other interactions of Frovatriptan
- Almotriptan + Frovatriptan Contraindicated
- Dihydroergotamine intranasal + Frovatriptan Contraindicated
- Dihydroergotamine + Frovatriptan Contraindicated
- Eletriptan + Frovatriptan Contraindicated
- Ergoloid mesylates + Frovatriptan Contraindicated
- Ergotamine + Frovatriptan Contraindicated
Frequently asked questions
Can I take Frovatriptan with Zileuton?
MediHelp rates the interaction as minor. Frovatriptan and Zileuton have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Frovatriptan is partly cleared by CYP1A2, so zileuton may modestly raise its concentrations. Clinical significance is likely small given the drug's wide tolerability.
How serious is the interaction between Frovatriptan and Zileuton?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed. Watch for triptan adverse effects such as dizziness, chest tightness or blood pressure rise.
What other medicines interact with Zileuton?
MediHelp also lists interactions of Zileuton with, for example, Fezolinetant, Pimozide, Alosetron. The full list is on the Zileuton page.
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