Drug interactions
Furosemide + Hydrochlorothiazide-losartan
Severity: Moderate
Furosemide and Hydrochlorothiazide-losartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Furosemide adds to the diuretic effect of hydrochlorothiazide, which can cause marked volume depletion, hypotension, renal impairment and electrolyte loss. Losartan may offset potassium loss but increases the risk of hypotension and kidney injury if the patient is volume depleted.
What this interaction means in plain words
Furosemide and Hydrochlorothiazide-losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Furosemide belongs to Cardiovascular; Hydrochlorothiazide-losartan belongs to Cardiovascular.
Why it happens
Sequential nephron blockade producing additive natriuresis and potassium wasting, with ARB-reduced glomerular filtration pressure.
What to do
Monitor blood pressure, renal function, sodium and potassium after starting or changing doses. Reduce diuretic doses if volume depletion develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Frequently asked questions
Can I take Furosemide with Hydrochlorothiazide-losartan?
MediHelp rates the interaction as moderate. Furosemide and Hydrochlorothiazide-losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Furosemide adds to the diuretic effect of hydrochlorothiazide, which can cause marked volume depletion, hypotension, renal impairment and electrolyte loss. Losartan may offset potassium loss but increases the risk of hypotension and kidney injury if the patient is volume depleted.
How serious is the interaction between Furosemide and Hydrochlorothiazide-losartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, renal function, sodium and potassium after starting or changing doses. Reduce diuretic doses if volume depletion develops.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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