Drug interactions
Furosemide + Indomethacin
Severity: Moderate
Furosemide and Indomethacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indomethacin can reduce the diuretic and natriuretic response to furosemide and may reduce its antihypertensive effect. Together they raise the risk of acute kidney injury, especially in volume-depleted patients.
What this interaction means in plain words
Furosemide and Indomethacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Furosemide belongs to Cardiovascular; Indomethacin belongs to Musculoskeletal.
Why it happens
NSAIDs inhibit renal prostaglandin synthesis, which is needed for loop diuretic-induced renal blood flow and natriuresis.
What to do
Monitor urine output, weight, blood pressure and renal function; a higher furosemide dose may be needed. Avoid in dehydrated patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Frequently asked questions
Can I take Furosemide with Indomethacin?
MediHelp rates the interaction as moderate. Furosemide and Indomethacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indomethacin can reduce the diuretic and natriuretic response to furosemide and may reduce its antihypertensive effect. Together they raise the risk of acute kidney injury, especially in volume-depleted patients.
How serious is the interaction between Furosemide and Indomethacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor urine output, weight, blood pressure and renal function; a higher furosemide dose may be needed. Avoid in dehydrated patients.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.
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