Drug interactions
Furosemide + Irbesartan
Severity: Moderate
Furosemide and Irbesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Volume depletion from furosemide makes renal perfusion dependent on angiotensin II, so adding irbesartan may cause hypotension and reduced renal function. Potassium effects oppose each other, making the net change unpredictable.
What this interaction means in plain words
Furosemide and Irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Furosemide belongs to Cardiovascular; Irbesartan belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic effects of volume depletion and angiotensin receptor blockade; opposing effects on potassium.
What to do
Monitor blood pressure, creatinine and potassium after initiation or dose changes. Reduce the diuretic dose if the patient is volume depleted.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Other interactions of Irbesartan
- Aliskiren + Irbesartan Contraindicated
- Irbesartan + Sparsentan Contraindicated
- Amifostine + Irbesartan Major
- Amiloride + Irbesartan Major
- Amlodipine-benazepril + Irbesartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Irbesartan Major
Frequently asked questions
Can I take Furosemide with Irbesartan?
MediHelp rates the interaction as moderate. Furosemide and Irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Volume depletion from furosemide makes renal perfusion dependent on angiotensin II, so adding irbesartan may cause hypotension and reduced renal function. Potassium effects oppose each other, making the net change unpredictable.
How serious is the interaction between Furosemide and Irbesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, creatinine and potassium after initiation or dose changes. Reduce the diuretic dose if the patient is volume depleted.
What other medicines interact with Furosemide?
MediHelp also lists interactions of Furosemide with, for example, Amifostine, Amikacin, Carbenoxolone. The full list is on the Furosemide page.
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