Drug interactions
Furosemide + Isoproterenol
Severity: Moderate
Furosemide and Isoproterenol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoproterenol stimulates beta-2 receptors and can drive potassium into cells, adding to furosemide's urinary potassium loss and increasing the risk of hypokalemia and arrhythmias.
What this interaction means in plain words
Furosemide and Isoproterenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Furosemide belongs to Cardiovascular; Isoproterenol belongs to Respiratory.
Why it happens
Additive hypokalemia from renal potassium wasting and beta-2 mediated intracellular potassium shift.
What to do
Monitor serum potassium and ECG during isoproterenol therapy in patients on furosemide, and replace potassium and magnesium as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Furosemide and Isoproterenol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Other interactions of Isoproterenol
Frequently asked questions
Can I take Furosemide with Isoproterenol?
MediHelp rates the interaction as moderate. Furosemide and Isoproterenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isoproterenol stimulates beta-2 receptors and can drive potassium into cells, adding to furosemide's urinary potassium loss and increasing the risk of hypokalemia and arrhythmias.
How serious is the interaction between Furosemide and Isoproterenol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and ECG during isoproterenol therapy in patients on furosemide, and replace potassium and magnesium as needed.
What other medicines interact with Furosemide?
MediHelp also lists interactions of Furosemide with, for example, Amifostine, Amikacin, Carbenoxolone. The full list is on the Furosemide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
