Drug interactions
Furosemide + L-methylfolate
Severity: Minor
Furosemide and L-methylfolate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chronic loop diuretic therapy may modestly increase urinary losses of folate forms. A clinically meaningful reduction in L-methylfolate effect is unlikely in most patients.
What this interaction means in plain words
Furosemide and L-methylfolate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Furosemide belongs to Cardiovascular; L-methylfolate belongs to Miscellaneous.
Why it happens
Increased renal excretion of folate with diuresis; the effect is theoretical and poorly characterized.
What to do
No dose change is usually needed; reassess folate status if deficiency symptoms or macrocytosis appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Other interactions of L-methylfolate
Frequently asked questions
Can I take Furosemide with L-methylfolate?
MediHelp rates the interaction as minor. Furosemide and L-methylfolate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Chronic loop diuretic therapy may modestly increase urinary losses of folate forms. A clinically meaningful reduction in L-methylfolate effect is unlikely in most patients.
How serious is the interaction between Furosemide and L-methylfolate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; reassess folate status if deficiency symptoms or macrocytosis appear.
What other medicines interact with Furosemide?
MediHelp also lists interactions of Furosemide with, for example, Amifostine, Amikacin, Carbenoxolone. The full list is on the Furosemide page.
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