Drug interactions
Furosemide + Leniolisib
Severity: Moderate
Furosemide and Leniolisib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Leniolisib may inhibit OAT3 and raise furosemide exposure, which could enhance diuresis and electrolyte disturbance.
What this interaction means in plain words
Furosemide and Leniolisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Furosemide belongs to Cardiovascular; Leniolisib belongs to Miscellaneous.
Why it happens
OAT3 inhibition by leniolisib reduces renal tubular secretion of furosemide.
What to do
Monitor fluid status, blood pressure and electrolytes, and reduce furosemide dose if excessive diuresis occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Leniolisib
Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Frequently asked questions
Can I take Furosemide with Leniolisib?
MediHelp rates the interaction as moderate. Furosemide and Leniolisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Leniolisib may inhibit OAT3 and raise furosemide exposure, which could enhance diuresis and electrolyte disturbance.
How serious is the interaction between Furosemide and Leniolisib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor fluid status, blood pressure and electrolytes, and reduce furosemide dose if excessive diuresis occurs.
What other medicines interact with Leniolisib?
MediHelp also lists interactions of Leniolisib with, for example, Amobarbital, Apalutamide, Carbamazepine. The full list is on the Leniolisib page.
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