Drug interactions
Furosemide + Linagliptin-metformin
Severity: Moderate
Furosemide and Linagliptin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Furosemide can raise metformin plasma concentrations, while metformin may modestly lower furosemide levels. Loop diuretics can also cause volume depletion and renal impairment, which raises the risk of metformin accumulation and lactic acidosis.
What this interaction means in plain words
Furosemide and Linagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Furosemide belongs to Cardiovascular; Linagliptin-metformin belongs to Endocrine.
Why it happens
Possible altered renal handling and protein-binding effects, plus diuretic-induced volume depletion that reduces metformin clearance.
What to do
Monitor renal function, hydration status and glycemic control, and reassess metformin dosing if renal function declines or dehydration occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Furosemide and Linagliptin-metformin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Linagliptin-metformin
Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Frequently asked questions
Can I take Furosemide with Linagliptin-metformin?
MediHelp rates the interaction as moderate. Furosemide and Linagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Furosemide can raise metformin plasma concentrations, while metformin may modestly lower furosemide levels. Loop diuretics can also cause volume depletion and renal impairment, which raises the risk of metformin accumulation and lactic acidosis.
How serious is the interaction between Furosemide and Linagliptin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function, hydration status and glycemic control, and reassess metformin dosing if renal function declines or dehydration occurs.
What other medicines interact with Linagliptin-metformin?
MediHelp also lists interactions of Linagliptin-metformin with, for example, Apalutamide, Carbamazepine, Contrast media. The full list is on the Linagliptin-metformin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
