Drug interactions
Furosemide + Magnesium
Severity: Moderate
Furosemide and Magnesium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Furosemide increases urinary magnesium excretion and commonly contributes to hypomagnesemia with chronic use. Low magnesium can worsen potassium depletion and raise arrhythmia risk, especially with digoxin or QT-prolonging drugs.
What this interaction means in plain words
Furosemide and Magnesium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Furosemide belongs to Cardiovascular; Magnesium belongs to Gastrointestinal Tract.
Why it happens
Inhibition of the Na-K-2Cl cotransporter in the thick ascending limb reduces magnesium reabsorption.
What to do
Monitor serum magnesium and potassium regularly during long-term therapy. Supplement magnesium as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Magnesium
- Ciprofloxacin + Magnesium Major
- Magnesium + Pancuronium Major
- Magnesium + Rocuronium Major
- Magnesium + Vecuronium Major
- Amikacin + Magnesium Moderate
- Amphotericin b deoxycholate + Magnesium Moderate
Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Frequently asked questions
Can I take Furosemide with Magnesium?
MediHelp rates the interaction as moderate. Furosemide and Magnesium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Furosemide increases urinary magnesium excretion and commonly contributes to hypomagnesemia with chronic use. Low magnesium can worsen potassium depletion and raise arrhythmia risk, especially with digoxin or QT-prolonging drugs.
How serious is the interaction between Furosemide and Magnesium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum magnesium and potassium regularly during long-term therapy. Supplement magnesium as needed.
What other medicines interact with Magnesium?
MediHelp also lists interactions of Magnesium with, for example, Ciprofloxacin, Pancuronium, Rocuronium. The full list is on the Magnesium page.
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