Drug interactions
Furosemide + Milnacipran
Severity: Moderate
Furosemide and Milnacipran: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can reduce serum sodium, so combined use may increase the risk of hyponatremia. Older patients are most susceptible, with symptoms such as confusion, headache and unsteadiness.
What this interaction means in plain words
Furosemide and Milnacipran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Furosemide belongs to Cardiovascular; Milnacipran belongs to Central Nervous System.
Why it happens
Diuretic-induced sodium loss combined with SNRI-associated SIADH produces additive hyponatremia.
What to do
Monitor serum sodium at baseline and after starting therapy, especially in the elderly. Reduce or stop milnacipran if hyponatremia becomes significant.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Other interactions of Milnacipran
- Isocarboxazid + Milnacipran Contraindicated
- Methylene blue + Milnacipran Contraindicated
- Milnacipran + Phenelzine Contraindicated
- Milnacipran + Procarbazine Contraindicated
- Milnacipran + Rasagiline Contraindicated
- Milnacipran + Safinamide Contraindicated
Frequently asked questions
Can I take Furosemide with Milnacipran?
MediHelp rates the interaction as moderate. Furosemide and Milnacipran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can reduce serum sodium, so combined use may increase the risk of hyponatremia. Older patients are most susceptible, with symptoms such as confusion, headache and unsteadiness.
How serious is the interaction between Furosemide and Milnacipran?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum sodium at baseline and after starting therapy, especially in the elderly. Reduce or stop milnacipran if hyponatremia becomes significant.
What other medicines interact with Furosemide?
MediHelp also lists interactions of Furosemide with, for example, Amifostine, Amikacin, Carbenoxolone. The full list is on the Furosemide page.
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