Drug interactions
Furosemide + Neomycin
Severity: Moderate
Furosemide and Neomycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Furosemide can increase the risk of aminoglycoside hearing damage and kidney injury. With oral neomycin this matters mainly when absorption is increased by renal impairment, bowel inflammation or prolonged therapy.
What this interaction means in plain words
Furosemide and Neomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Furosemide belongs to Cardiovascular; Neomycin belongs to Anti Bacterial.
Why it happens
Additive ototoxicity and nephrotoxicity, with diuretic-related volume depletion increasing exposure to absorbed neomycin.
What to do
Monitor renal function and hearing if neomycin is used long term or in renal impairment. Maintain hydration and avoid high doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Neomycin
- Amikacin + Neomycin Major
- Amphotericin b deoxycholate + Neomycin Major
- Capreomycin + Neomycin Major
- Cidofovir + Neomycin Major
- Colistin + Neomycin Major
- Ethacrynic acid + Neomycin Major
Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Frequently asked questions
Can I take Furosemide with Neomycin?
MediHelp rates the interaction as moderate. Furosemide and Neomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Furosemide can increase the risk of aminoglycoside hearing damage and kidney injury. With oral neomycin this matters mainly when absorption is increased by renal impairment, bowel inflammation or prolonged therapy.
How serious is the interaction between Furosemide and Neomycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and hearing if neomycin is used long term or in renal impairment. Maintain hydration and avoid high doses.
What other medicines interact with Neomycin?
MediHelp also lists interactions of Neomycin with, for example, Amikacin, Amphotericin b deoxycholate, Capreomycin. The full list is on the Neomycin page.
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