Drug interactions
Furosemide + Saxagliptin-metformin
Severity: Moderate
Furosemide and Saxagliptin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Furosemide can raise metformin concentrations, and loop diuretics may also worsen glycemic control or cause volume depletion and renal impairment. This may increase the risk of metformin accumulation and lactic acidosis in susceptible patients.
What this interaction means in plain words
Furosemide and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Furosemide belongs to Cardiovascular; Saxagliptin-metformin belongs to Endocrine.
Why it happens
Furosemide may reduce metformin renal clearance and displace it from plasma protein, while volume depletion can impair renal function.
What to do
Monitor blood glucose, hydration status and renal function, and reassess metformin dose if eGFR falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Saxagliptin-metformin
Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Frequently asked questions
Can I take Furosemide with Saxagliptin-metformin?
MediHelp rates the interaction as moderate. Furosemide and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Furosemide can raise metformin concentrations, and loop diuretics may also worsen glycemic control or cause volume depletion and renal impairment. This may increase the risk of metformin accumulation and lactic acidosis in susceptible patients.
How serious is the interaction between Furosemide and Saxagliptin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose, hydration status and renal function, and reassess metformin dose if eGFR falls.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
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