Drug interactions
Furosemide + Sertraline
Severity: Moderate
Furosemide and Sertraline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can lower serum sodium, so using them together raises the risk of hyponatremia. Older adults are particularly susceptible, with confusion, headache or falls as possible presentations.
What this interaction means in plain words
Furosemide and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Furosemide belongs to Cardiovascular; Sertraline belongs to Central Nervous System.
Why it happens
Diuretic-induced sodium loss combined with SSRI-associated SIADH produces additive hyponatremia.
What to do
Measure serum sodium at baseline and shortly after starting treatment, especially in older patients. Review the antidepressant if sodium falls significantly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Frequently asked questions
Can I take Furosemide with Sertraline?
MediHelp rates the interaction as moderate. Furosemide and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can lower serum sodium, so using them together raises the risk of hyponatremia. Older adults are particularly susceptible, with confusion, headache or falls as possible presentations.
How serious is the interaction between Furosemide and Sertraline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Measure serum sodium at baseline and shortly after starting treatment, especially in older patients. Review the antidepressant if sodium falls significantly.
What other medicines interact with Furosemide?
MediHelp also lists interactions of Furosemide with, for example, Amifostine, Amikacin, Carbenoxolone. The full list is on the Furosemide page.
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