Drug interactions
Furosemide + Sulindac
Severity: Moderate
Furosemide and Sulindac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce the diuretic and natriuretic response to loop diuretics and may blunt their antihypertensive effect. In volume-depleted or susceptible patients the combination can also impair renal function.
What this interaction means in plain words
Furosemide and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Furosemide belongs to Cardiovascular; Sulindac belongs to Musculoskeletal.
Why it happens
NSAIDs inhibit renal prostaglandin synthesis, causing sodium and water retention and reducing renal blood flow, which antagonizes loop diuretic action (sulindac may do so less than other NSAIDs).
What to do
Monitor blood pressure, weight, edema and serum creatinine and electrolytes. Increase the diuretic dose if response is reduced, or stop the NSAID.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Frequently asked questions
Can I take Furosemide with Sulindac?
MediHelp rates the interaction as moderate. Furosemide and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can reduce the diuretic and natriuretic response to loop diuretics and may blunt their antihypertensive effect. In volume-depleted or susceptible patients the combination can also impair renal function.
How serious is the interaction between Furosemide and Sulindac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, weight, edema and serum creatinine and electrolytes. Increase the diuretic dose if response is reduced, or stop the NSAID.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
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