Drug interactions
Furosemide + Tolfenamic acid
Severity: Moderate
Furosemide and Tolfenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as tolfenamic acid can blunt the diuretic and antihypertensive effect of furosemide and may precipitate acute kidney injury in volume-depleted patients. Sodium and fluid retention can worsen heart failure or hypertension control.
What this interaction means in plain words
Furosemide and Tolfenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Furosemide belongs to Cardiovascular; Tolfenamic acid belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandin synthesis reduces renal blood flow and sodium excretion, antagonizing loop diuretic action.
What to do
Avoid regular NSAID use where possible, or use the lowest dose for the shortest time. Monitor blood pressure, weight, edema and serum creatinine, and ensure adequate hydration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Other interactions of Tolfenamic acid
Frequently asked questions
Can I take Furosemide with Tolfenamic acid?
MediHelp rates the interaction as moderate. Furosemide and Tolfenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as tolfenamic acid can blunt the diuretic and antihypertensive effect of furosemide and may precipitate acute kidney injury in volume-depleted patients. Sodium and fluid retention can worsen heart failure or hypertension control.
How serious is the interaction between Furosemide and Tolfenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular NSAID use where possible, or use the lowest dose for the shortest time. Monitor blood pressure, weight, edema and serum creatinine, and ensure adequate hydration.
What other medicines interact with Furosemide?
MediHelp also lists interactions of Furosemide with, for example, Amifostine, Amikacin, Carbenoxolone. The full list is on the Furosemide page.
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