Drug interactions
Furosemide + Umeclidinium-vilanterol
Severity: Moderate
Furosemide and Umeclidinium-vilanterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Furosemide causes renal potassium loss, and vilanterol can further lower serum potassium through intracellular shift. The combination may cause hypokalemia and ECG changes, particularly with excessive beta-agonist use.
What this interaction means in plain words
Furosemide and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Furosemide belongs to Cardiovascular; Umeclidinium-vilanterol belongs to Respiratory.
Why it happens
Additive hypokalemia from loop-diuretic potassium wasting and beta2-mediated cellular potassium uptake.
What to do
Monitor serum potassium and magnesium, particularly when starting therapy or during exacerbations. Supplement potassium if needed and avoid exceeding the labeled inhaler dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Umeclidinium-vilanterol
Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Frequently asked questions
Can I take Furosemide with Umeclidinium-vilanterol?
MediHelp rates the interaction as moderate. Furosemide and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Furosemide causes renal potassium loss, and vilanterol can further lower serum potassium through intracellular shift. The combination may cause hypokalemia and ECG changes, particularly with excessive beta-agonist use.
How serious is the interaction between Furosemide and Umeclidinium-vilanterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium, particularly when starting therapy or during exacerbations. Supplement potassium if needed and avoid exceeding the labeled inhaler dose.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
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