Drug interactions
Furosemide + Vitamin b1
Severity: Minor
Furosemide and Vitamin b1: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Furosemide increases urinary excretion of thiamine, and long-term use has been associated with lowered thiamine status. This is most relevant in patients with heart failure, poor nutrition or high alcohol intake, where deficiency may worsen cardiac function.
What this interaction means in plain words
Furosemide and Vitamin b1 have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Furosemide belongs to Cardiovascular; Vitamin b1 belongs to Gastrointestinal Tract.
Why it happens
Enhanced renal loss of thiamine due to loop diuretic-induced diuresis.
What to do
In patients on chronic furosemide with risk factors for deficiency, consider thiamine supplementation and monitor for clinical signs of deficiency.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Vitamin b1
- Ethanol + Vitamin b1 Major
- Bumetanide + Vitamin b1 Minor
- Ethacrynic acid + Vitamin b1 Minor
- Omadacycline + Vitamin b1 Minor
- Patiromer + Vitamin b1 Minor
- Torsemide + Vitamin b1 Minor
Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Frequently asked questions
Can I take Furosemide with Vitamin b1?
MediHelp rates the interaction as minor. Furosemide and Vitamin b1 have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Furosemide increases urinary excretion of thiamine, and long-term use has been associated with lowered thiamine status. This is most relevant in patients with heart failure, poor nutrition or high alcohol intake, where deficiency may worsen cardiac function.
How serious is the interaction between Furosemide and Vitamin b1?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: In patients on chronic furosemide with risk factors for deficiency, consider thiamine supplementation and monitor for clinical signs of deficiency.
What other medicines interact with Vitamin b1?
MediHelp also lists interactions of Vitamin b1 with, for example, Ethanol, Bumetanide, Ethacrynic acid. The full list is on the Vitamin b1 page.
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