Drug interactions
Omadacycline + Vitamin b1
Severity: Minor
Omadacycline and Vitamin b1: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Multivalent cations can chelate oral tetracyclines and reduce absorption. Plain thiamine contains little multivalent cation, so a significant effect is unlikely unless the product is combined with minerals.
What this interaction means in plain words
Omadacycline and Vitamin b1 have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Omadacycline belongs to Anti Bacterial; Vitamin b1 belongs to Gastrointestinal Tract.
Why it happens
Chelation by multivalent cations in the gut would reduce tetracycline absorption; thiamine itself is not a significant chelator.
What to do
If thiamine is in a mineral-containing multivitamin, separate it from oral omadacycline according to the omadacycline labeling.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Vitamin b1
- Ethanol + Vitamin b1 Major
- Bumetanide + Vitamin b1 Minor
- Ethacrynic acid + Vitamin b1 Minor
- Furosemide + Vitamin b1 Minor
- Patiromer + Vitamin b1 Minor
- Torsemide + Vitamin b1 Minor
Other interactions of Omadacycline
- Acitretin + Omadacycline Contraindicated
- Isotretinoin + Omadacycline Major
- Omadacycline + Tretinoin Major
- Aluminum hydroxide + Omadacycline Moderate
- Amoxicillin-clavulanic acid + Omadacycline Moderate
- Amoxicillin + Omadacycline Moderate
Frequently asked questions
Can I take Omadacycline with Vitamin b1?
MediHelp rates the interaction as minor. Omadacycline and Vitamin b1 have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Multivalent cations can chelate oral tetracyclines and reduce absorption. Plain thiamine contains little multivalent cation, so a significant effect is unlikely unless the product is combined with minerals.
How serious is the interaction between Omadacycline and Vitamin b1?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If thiamine is in a mineral-containing multivitamin, separate it from oral omadacycline according to the omadacycline labeling.
What other medicines interact with Vitamin b1?
MediHelp also lists interactions of Vitamin b1 with, for example, Ethanol, Bumetanide, Ethacrynic acid. The full list is on the Vitamin b1 page.
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