Drug interactions
Gabapentin + Metoclopramide
Severity: Moderate
Gabapentin and Metoclopramide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs may cause drowsiness, dizziness and impaired coordination. Combined use may increase CNS adverse effects, especially in older or renally impaired patients.
What this interaction means in plain words
Gabapentin and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gabapentin belongs to Central Nervous System; Metoclopramide belongs to Gastrointestinal Tract.
Why it happens
Additive CNS depressant effects.
What to do
Use the lowest effective doses and monitor for sedation and dizziness. Adjust doses for renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoclopramide
Other interactions of Gabapentin
Frequently asked questions
Can I take Gabapentin with Metoclopramide?
MediHelp rates the interaction as moderate. Gabapentin and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs may cause drowsiness, dizziness and impaired coordination. Combined use may increase CNS adverse effects, especially in older or renally impaired patients.
How serious is the interaction between Gabapentin and Metoclopramide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for sedation and dizziness. Adjust doses for renal function.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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