Drug interactions
Gabapentin + Vilazodone
Severity: Moderate
Gabapentin and Vilazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gabapentin causes sedation, dizziness and, particularly with other CNS-active drugs, respiratory depression. Combined with vilazodone, additive drowsiness and psychomotor impairment may occur, and serotonergic antidepressants may add to cognitive effects.
What this interaction means in plain words
Gabapentin and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gabapentin belongs to Central Nervous System; Vilazodone belongs to Central Nervous System.
Why it happens
Additive central nervous system depressant effects (pharmacodynamic).
What to do
Start gabapentin at a low dose and titrate slowly, monitoring for sedation, dizziness and respiratory depression. Counsel patients about driving and alcohol, and take extra care in elderly patients and those with lung disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vilazodone
- Isocarboxazid + Vilazodone Contraindicated
- Methylene blue + Vilazodone Contraindicated
- Phenelzine + Vilazodone Contraindicated
- Rasagiline + Vilazodone Contraindicated
- Selegiline transdermal + Vilazodone Contraindicated
- Selegiline + Vilazodone Contraindicated
Other interactions of Gabapentin
Frequently asked questions
Can I take Gabapentin with Vilazodone?
MediHelp rates the interaction as moderate. Gabapentin and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gabapentin causes sedation, dizziness and, particularly with other CNS-active drugs, respiratory depression. Combined with vilazodone, additive drowsiness and psychomotor impairment may occur, and serotonergic antidepressants may add to cognitive effects.
How serious is the interaction between Gabapentin and Vilazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start gabapentin at a low dose and titrate slowly, monitoring for sedation, dizziness and respiratory depression. Counsel patients about driving and alcohol, and take extra care in elderly patients and those with lung disease.
What other medicines interact with Vilazodone?
MediHelp also lists interactions of Vilazodone with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Vilazodone page.
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