Drug interactions
Galantamine + Hyoscyamine
Severity: Moderate
Galantamine and Hyoscyamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hyoscyamine blocks muscarinic receptors and counteracts galantamine, reducing its therapeutic effect. It can also worsen confusion in people with dementia.
What this interaction means in plain words
Galantamine and Hyoscyamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Galantamine belongs to Central Nervous System; Hyoscyamine belongs to Genitourinary.
Why it happens
Pharmacodynamic antagonism between cholinesterase inhibition and muscarinic blockade.
What to do
Avoid hyoscyamine in patients on galantamine when alternatives exist. If needed, monitor cognition and response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Galantamine
- Galantamine + Memantine-donepezil Major
- Galantamine + Physostigmine Major
- Galantamine + Ponesimod Major
- Galantamine + Rivastigmine Major
- Amifampridine + Galantamine Moderate
- Amiodarone + Galantamine Moderate
Other interactions of Hyoscyamine
- Amantadine + Hyoscyamine Moderate
- Amitriptyline + Hyoscyamine Moderate
- Aripiprazole + Hyoscyamine Moderate
- Atropine + Hyoscyamine Moderate
- Benztropine + Hyoscyamine Moderate
- Bethanechol + Hyoscyamine Moderate
Frequently asked questions
Can I take Galantamine with Hyoscyamine?
MediHelp rates the interaction as moderate. Galantamine and Hyoscyamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hyoscyamine blocks muscarinic receptors and counteracts galantamine, reducing its therapeutic effect. It can also worsen confusion in people with dementia.
How serious is the interaction between Galantamine and Hyoscyamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid hyoscyamine in patients on galantamine when alternatives exist. If needed, monitor cognition and response.
What other medicines interact with Galantamine?
MediHelp also lists interactions of Galantamine with, for example, Memantine-donepezil, Physostigmine, Ponesimod. The full list is on the Galantamine page.
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