Drug interactions
Galantamine + Levoketoconazole
Severity: Moderate
Galantamine and Levoketoconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levoketoconazole is a strong CYP3A4 inhibitor and can raise galantamine concentrations. Exposure to galantamine rises with ketoconazole, increasing the risk of cholinergic effects like nausea, vomiting and bradycardia.
What this interaction means in plain words
Galantamine and Levoketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Galantamine belongs to Central Nervous System; Levoketoconazole belongs to Endocrine.
Why it happens
Inhibition of CYP3A4-mediated galantamine metabolism.
What to do
Monitor for cholinergic adverse effects and heart rate, and reduce the galantamine dose if they occur. Be aware that levoketoconazole also inhibits CYP2D6.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Galantamine
- Galantamine + Memantine-donepezil Major
- Galantamine + Physostigmine Major
- Galantamine + Ponesimod Major
- Galantamine + Rivastigmine Major
- Amifampridine + Galantamine Moderate
- Amiodarone + Galantamine Moderate
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Galantamine with Levoketoconazole?
MediHelp rates the interaction as moderate. Galantamine and Levoketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levoketoconazole is a strong CYP3A4 inhibitor and can raise galantamine concentrations. Exposure to galantamine rises with ketoconazole, increasing the risk of cholinergic effects like nausea, vomiting and bradycardia.
How serious is the interaction between Galantamine and Levoketoconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for cholinergic adverse effects and heart rate, and reduce the galantamine dose if they occur. Be aware that levoketoconazole also inhibits CYP2D6.
What other medicines interact with Galantamine?
MediHelp also lists interactions of Galantamine with, for example, Memantine-donepezil, Physostigmine, Ponesimod. The full list is on the Galantamine page.
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