Drug interactions
Galantamine + Ranolazine
Severity: Minor
Galantamine and Ranolazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ranolazine inhibits CYP2D6, which partly metabolizes galantamine, so galantamine exposure may increase. This could heighten cholinergic effects such as nausea, vomiting and bradycardia.
What this interaction means in plain words
Galantamine and Ranolazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Galantamine belongs to Central Nervous System; Ranolazine belongs to Cardiovascular.
Why it happens
Ranolazine inhibits CYP2D6-mediated metabolism of galantamine.
What to do
Monitor heart rate and gastrointestinal tolerance. Slow galantamine titration or lower the dose if bradycardia or marked nausea develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Other interactions of Galantamine
- Galantamine + Memantine-donepezil Major
- Galantamine + Physostigmine Major
- Galantamine + Ponesimod Major
- Galantamine + Rivastigmine Major
- Amifampridine + Galantamine Moderate
- Amiodarone + Galantamine Moderate
Frequently asked questions
Can I take Galantamine with Ranolazine?
MediHelp rates the interaction as minor. Galantamine and Ranolazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ranolazine inhibits CYP2D6, which partly metabolizes galantamine, so galantamine exposure may increase. This could heighten cholinergic effects such as nausea, vomiting and bradycardia.
How serious is the interaction between Galantamine and Ranolazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and gastrointestinal tolerance. Slow galantamine titration or lower the dose if bradycardia or marked nausea develops.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
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