Drug interactions
Ganaxolone + Mirtazapine
Severity: Moderate
Ganaxolone and Mirtazapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ganaxolone is a neuroactive steroid GABA-A modulator that causes somnolence and sedation. Adding mirtazapine can increase drowsiness and impair alertness.
What this interaction means in plain words
Ganaxolone and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ganaxolone belongs to Central Nervous System; Mirtazapine belongs to Central Nervous System.
Why it happens
Additive CNS depression from GABA-A modulation and histamine H1 antagonism.
What to do
Monitor for excessive sedation and reduce doses if needed. Advise patients and caregivers about impaired alertness and fall risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Other interactions of Ganaxolone
Frequently asked questions
Can I take Ganaxolone with Mirtazapine?
MediHelp rates the interaction as moderate. Ganaxolone and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ganaxolone is a neuroactive steroid GABA-A modulator that causes somnolence and sedation. Adding mirtazapine can increase drowsiness and impair alertness.
How serious is the interaction between Ganaxolone and Mirtazapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and reduce doses if needed. Advise patients and caregivers about impaired alertness and fall risk.
What other medicines interact with Mirtazapine?
MediHelp also lists interactions of Mirtazapine with, for example, Isocarboxazid, Phenelzine, Pimozide. The full list is on the Mirtazapine page.
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