Drug interactions
Ganaxolone + Modafinil
Severity: Moderate
Ganaxolone and Modafinil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ganaxolone is a CYP3A4 substrate, and modafinil's CYP3A4 induction may lower its concentrations. This could reduce seizure control in patients with CDKL5 deficiency disorder.
What this interaction means in plain words
Ganaxolone and Modafinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ganaxolone belongs to Central Nervous System; Modafinil belongs to Central Nervous System.
Why it happens
Modafinil induces CYP3A4, increasing ganaxolone clearance.
What to do
Monitor seizure frequency and consider increasing the ganaxolone dose within the weight-based maximum, or use an alternative to modafinil.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Modafinil
Other interactions of Ganaxolone
Frequently asked questions
Can I take Ganaxolone with Modafinil?
MediHelp rates the interaction as moderate. Ganaxolone and Modafinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ganaxolone is a CYP3A4 substrate, and modafinil's CYP3A4 induction may lower its concentrations. This could reduce seizure control in patients with CDKL5 deficiency disorder.
How serious is the interaction between Ganaxolone and Modafinil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor seizure frequency and consider increasing the ganaxolone dose within the weight-based maximum, or use an alternative to modafinil.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lorlatinib. The full list is on the Modafinil page.
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