Drug interactions
Ganaxolone + Phenobarbitone
Severity: Moderate
Ganaxolone and Phenobarbitone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenobarbitone can reduce ganaxolone concentrations and may weaken its anticonvulsant effect. Additive sedation is also possible.
What this interaction means in plain words
Ganaxolone and Phenobarbitone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ganaxolone belongs to Central Nervous System; Phenobarbitone belongs to Central Nervous System.
Why it happens
CYP3A4 induction by phenobarbitone increases ganaxolone clearance, plus additive CNS depression.
What to do
Monitor seizure control and sedation; adjust ganaxolone dose within the maximum daily dose if response is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ganaxolone
Other interactions of Phenobarbitone
- Cabotegravir + Phenobarbitone Contraindicated
- Doravirine + Phenobarbitone Contraindicated
- Isavuconazole + Phenobarbitone Contraindicated
- Darolutamide + Phenobarbitone Major
- Finerenone + Phenobarbitone Major
- Ivacaftor + Phenobarbitone Major
Frequently asked questions
Can I take Ganaxolone with Phenobarbitone?
MediHelp rates the interaction as moderate. Ganaxolone and Phenobarbitone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenobarbitone can reduce ganaxolone concentrations and may weaken its anticonvulsant effect. Additive sedation is also possible.
How serious is the interaction between Ganaxolone and Phenobarbitone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor seizure control and sedation; adjust ganaxolone dose within the maximum daily dose if response is lost.
What other medicines interact with Ganaxolone?
MediHelp also lists interactions of Ganaxolone with, for example, Amobarbital, Apalutamide, Armodafinil. The full list is on the Ganaxolone page.
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