Drug interactions
Ganaxolone + Sevoflurane
Severity: Moderate
Ganaxolone and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ganaxolone is a sedating neuroactive steroid and can add to the CNS depression produced by sevoflurane. Excess sedation, slowed recovery and respiratory depression are possible.
What this interaction means in plain words
Ganaxolone and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ganaxolone belongs to Central Nervous System; Sevoflurane belongs to Central Nervous System.
Why it happens
Additive CNS depression, since ganaxolone is a positive modulator of GABA-A receptors like volatile anesthetics.
What to do
Adjust sevoflurane to clinical effect and monitor sedation and ventilation, including during recovery. Continue ganaxolone as prescribed unless the anesthesia team advises otherwise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sevoflurane
Other interactions of Ganaxolone
Frequently asked questions
Can I take Ganaxolone with Sevoflurane?
MediHelp rates the interaction as moderate. Ganaxolone and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ganaxolone is a sedating neuroactive steroid and can add to the CNS depression produced by sevoflurane. Excess sedation, slowed recovery and respiratory depression are possible.
How serious is the interaction between Ganaxolone and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Adjust sevoflurane to clinical effect and monitor sedation and ventilation, including during recovery. Continue ganaxolone as prescribed unless the anesthesia team advises otherwise.
What other medicines interact with Sevoflurane?
MediHelp also lists interactions of Sevoflurane with, for example, Amiodarone, Amisulpride, Arsenic trioxide. The full list is on the Sevoflurane page.
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