Drug interactions
Ganaxolone + Trazodone
Severity: Moderate
Ganaxolone and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ganaxolone, a neuroactive steroid, causes somnolence and sedation. Combined with trazodone, sedation may be increased and psychomotor performance impaired.
What this interaction means in plain words
Ganaxolone and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ganaxolone belongs to Central Nervous System; Trazodone belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects.
What to do
Monitor for excessive sedation and reduce doses if needed. Advise against driving or other hazardous activities until the effect is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Other interactions of Ganaxolone
Frequently asked questions
Can I take Ganaxolone with Trazodone?
MediHelp rates the interaction as moderate. Ganaxolone and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ganaxolone, a neuroactive steroid, causes somnolence and sedation. Combined with trazodone, sedation may be increased and psychomotor performance impaired.
How serious is the interaction between Ganaxolone and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and reduce doses if needed. Advise against driving or other hazardous activities until the effect is known.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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