Drug interactions
Ganciclovir + Nitisinone
Severity: Moderate
Ganciclovir and Nitisinone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nitisinone may raise ganciclovir concentrations by reducing its renal elimination. This can increase myelosuppression and other dose-related toxicity.
What this interaction means in plain words
Ganciclovir and Nitisinone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ganciclovir belongs to Anti Virals; Nitisinone belongs to Miscellaneous.
Why it happens
Nitisinone inhibits OAT1/OAT3-mediated renal tubular secretion of ganciclovir.
What to do
Monitor blood counts and renal function during co-administration. Adjust the ganciclovir dose if toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nitisinone
- Adefovir + Nitisinone Moderate
- Bosentan + Nitisinone Moderate
- Celecoxib + Nitisinone Moderate
- Chlorpropamide + Nitisinone Moderate
- Diclofenac + Nitisinone Moderate
- Fluvastatin + Nitisinone Moderate
Other interactions of Ganciclovir
Frequently asked questions
Can I take Ganciclovir with Nitisinone?
MediHelp rates the interaction as moderate. Ganciclovir and Nitisinone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nitisinone may raise ganciclovir concentrations by reducing its renal elimination. This can increase myelosuppression and other dose-related toxicity.
How serious is the interaction between Ganciclovir and Nitisinone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and renal function during co-administration. Adjust the ganciclovir dose if toxicity appears.
What other medicines interact with Nitisinone?
MediHelp also lists interactions of Nitisinone with, for example, Adefovir, Bosentan, Celecoxib. The full list is on the Nitisinone page.
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