Drug interactions
Garlic + Vortioxetine
Severity: Minor
Garlic and Vortioxetine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vortioxetine, like other serotonergic antidepressants, can impair platelet serotonin uptake and increase bleeding risk. Garlic supplements have antiplatelet activity that could add to this. The combination may modestly raise the risk of bruising or bleeding.
What this interaction means in plain words
Garlic and Vortioxetine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Garlic belongs to Gastrointestinal Tract; Vortioxetine belongs to Central Nervous System.
Why it happens
Additive impairment of platelet function via serotonin reuptake inhibition and garlic's antiplatelet constituents.
What to do
Counsel patients to report unusual bruising or bleeding and avoid high-dose garlic supplements, especially if other antithrombotics are used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Garlic
- Garlic + Saquinavir Major
- Aceclofenac + Garlic Moderate
- Acemetacin + Garlic Moderate
- Aescin + Garlic Moderate
- Alteplase + Garlic Moderate
- Argatroban + Garlic Moderate
Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
Frequently asked questions
Can I take Garlic with Vortioxetine?
MediHelp rates the interaction as minor. Garlic and Vortioxetine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Vortioxetine, like other serotonergic antidepressants, can impair platelet serotonin uptake and increase bleeding risk. Garlic supplements have antiplatelet activity that could add to this. The combination may modestly raise the risk of bruising or bleeding.
How serious is the interaction between Garlic and Vortioxetine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to report unusual bruising or bleeding and avoid high-dose garlic supplements, especially if other antithrombotics are used.
What other medicines interact with Garlic?
MediHelp also lists interactions of Garlic with, for example, Saquinavir, Aceclofenac, Acemetacin. The full list is on the Garlic page.
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