Drug interactions
Gefitinib + Itraconazole
Severity: Moderate
Gefitinib and Itraconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole increases gefitinib exposure, which may increase adverse effects such as diarrhea, rash, interstitial lung disease and liver enzyme elevation.
What this interaction means in plain words
Gefitinib and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gefitinib belongs to Oncology; Itraconazole belongs to Anti Fungals.
Why it happens
Inhibition of CYP3A4-mediated gefitinib metabolism.
What to do
Monitor closely for gefitinib adverse reactions during coadministration. Consider an alternative antifungal if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Gefitinib
Frequently asked questions
Can I take Gefitinib with Itraconazole?
MediHelp rates the interaction as moderate. Gefitinib and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Itraconazole increases gefitinib exposure, which may increase adverse effects such as diarrhea, rash, interstitial lung disease and liver enzyme elevation.
How serious is the interaction between Gefitinib and Itraconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor closely for gefitinib adverse reactions during coadministration. Consider an alternative antifungal if toxicity occurs.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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