Drug interactions
Gefitinib + Ribociclib
Severity: Moderate
Gefitinib and Ribociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gefitinib is mainly metabolized by CYP3A4, so ribociclib may increase gefitinib exposure. This may worsen diarrhea, rash, interstitial lung disease and liver enzyme elevation.
What this interaction means in plain words
Gefitinib and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gefitinib belongs to Oncology; Ribociclib belongs to Oncology.
Why it happens
Ribociclib inhibits CYP3A4, reducing gefitinib clearance.
What to do
Monitor for gefitinib toxicity including diarrhea, skin reactions and liver tests. Interrupt or reduce gefitinib as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Other interactions of Gefitinib
Frequently asked questions
Can I take Gefitinib with Ribociclib?
MediHelp rates the interaction as moderate. Gefitinib and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gefitinib is mainly metabolized by CYP3A4, so ribociclib may increase gefitinib exposure. This may worsen diarrhea, rash, interstitial lung disease and liver enzyme elevation.
How serious is the interaction between Gefitinib and Ribociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for gefitinib toxicity including diarrhea, skin reactions and liver tests. Interrupt or reduce gefitinib as needed.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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