Drug interactions
Gefitinib + Voriconazole
Severity: Moderate
Gefitinib and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole may raise gefitinib concentrations, increasing the risk of adverse effects such as diarrhea, skin reactions, hepatotoxicity and interstitial lung disease.
What this interaction means in plain words
Gefitinib and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gefitinib belongs to Oncology; Voriconazole belongs to Anti Fungals.
Why it happens
Voriconazole inhibits CYP3A4, the main pathway of gefitinib metabolism.
What to do
Monitor for gefitinib toxicity and liver function; consider dose interruption if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Gefitinib
Frequently asked questions
Can I take Gefitinib with Voriconazole?
MediHelp rates the interaction as moderate. Gefitinib and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voriconazole may raise gefitinib concentrations, increasing the risk of adverse effects such as diarrhea, skin reactions, hepatotoxicity and interstitial lung disease.
How serious is the interaction between Gefitinib and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for gefitinib toxicity and liver function; consider dose interruption if adverse effects occur.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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