Drug interactions
Gemfibrozil + Gliclazide
Severity: Moderate
Gemfibrozil and Gliclazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gemfibrozil may increase the glucose-lowering effect of gliclazide and has been linked to hypoglycemia. Gemfibrozil inhibits CYP2C9, which contributes to gliclazide metabolism.
What this interaction means in plain words
Gemfibrozil and Gliclazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gemfibrozil belongs to Cardiovascular; Gliclazide belongs to Endocrine.
Why it happens
Gemfibrozil inhibits CYP2C9 and may displace sulfonylureas from protein binding, raising gliclazide exposure.
What to do
Monitor blood glucose when gemfibrozil is started or stopped. Reduce the gliclazide dose if hypoglycemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gliclazide
Other interactions of Gemfibrozil
- Daprodustat + Gemfibrozil Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Gemfibrozil + Mavacamten Contraindicated
- Gemfibrozil + Metformin-repaglinide Contraindicated
- Gemfibrozil + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Gemfibrozil + Repaglinide Contraindicated
Frequently asked questions
Can I take Gemfibrozil with Gliclazide?
MediHelp rates the interaction as moderate. Gemfibrozil and Gliclazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gemfibrozil may increase the glucose-lowering effect of gliclazide and has been linked to hypoglycemia. Gemfibrozil inhibits CYP2C9, which contributes to gliclazide metabolism.
How serious is the interaction between Gemfibrozil and Gliclazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when gemfibrozil is started or stopped. Reduce the gliclazide dose if hypoglycemia develops.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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