Drug interactions
Gemfibrozil + Glipizide-metformin
Severity: Moderate
Gemfibrozil and Glipizide-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gemfibrozil may increase glipizide effect and produce hypoglycemia. Gemfibrozil inhibits CYP2C9 and is highly protein bound, which may raise sulfonylurea exposure. Risk is greater with low albumin or renal impairment.
What this interaction means in plain words
Gemfibrozil and Glipizide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gemfibrozil belongs to Cardiovascular; Glipizide-metformin belongs to Endocrine.
Why it happens
Inhibition of CYP2C9 metabolism and possible displacement from plasma protein binding sites.
What to do
Monitor blood glucose when starting or stopping gemfibrozil. Reduce the glipizide dose if hypoglycemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Other interactions of Gemfibrozil
- Daprodustat + Gemfibrozil Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Gemfibrozil + Mavacamten Contraindicated
- Gemfibrozil + Metformin-repaglinide Contraindicated
- Gemfibrozil + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Gemfibrozil + Repaglinide Contraindicated
Frequently asked questions
Can I take Gemfibrozil with Glipizide-metformin?
MediHelp rates the interaction as moderate. Gemfibrozil and Glipizide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gemfibrozil may increase glipizide effect and produce hypoglycemia. Gemfibrozil inhibits CYP2C9 and is highly protein bound, which may raise sulfonylurea exposure. Risk is greater with low albumin or renal impairment.
How serious is the interaction between Gemfibrozil and Glipizide-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping gemfibrozil. Reduce the glipizide dose if hypoglycemia develops.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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