Drug interactions
Gemfibrozil + Glyburide-metformin
Severity: Moderate
Gemfibrozil and Glyburide-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gemfibrozil may increase glyburide exposure and has been associated with enhanced hypoglycemia. The risk is greater in patients with low albumin or reduced renal function.
What this interaction means in plain words
Gemfibrozil and Glyburide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gemfibrozil belongs to Cardiovascular; Glyburide-metformin belongs to Endocrine.
Why it happens
Inhibition of CYP2C9 and possibly transporter-mediated clearance of glyburide, with protein binding displacement.
What to do
Monitor blood glucose when starting or stopping gemfibrozil and reduce the glyburide dose if hypoglycemia occurs. Consider fenofibrate as an alternative if appropriate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Other interactions of Gemfibrozil
- Daprodustat + Gemfibrozil Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Gemfibrozil + Mavacamten Contraindicated
- Gemfibrozil + Metformin-repaglinide Contraindicated
- Gemfibrozil + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Gemfibrozil + Repaglinide Contraindicated
Frequently asked questions
Can I take Gemfibrozil with Glyburide-metformin?
MediHelp rates the interaction as moderate. Gemfibrozil and Glyburide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gemfibrozil may increase glyburide exposure and has been associated with enhanced hypoglycemia. The risk is greater in patients with low albumin or reduced renal function.
How serious is the interaction between Gemfibrozil and Glyburide-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping gemfibrozil and reduce the glyburide dose if hypoglycemia occurs. Consider fenofibrate as an alternative if appropriate.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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