Drug interactions
Gemfibrozil + Sacubitril-valsartan
Severity: Minor
Gemfibrozil and Sacubitril-valsartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gemfibrozil inhibits hepatic OATP1B1 uptake, and valsartan is a substrate of this transporter, so valsartan exposure may increase. This could enhance hypotension, hyperkalemia or renal effects, although the clinical significance is probably modest.
What this interaction means in plain words
Gemfibrozil and Sacubitril-valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Gemfibrozil belongs to Cardiovascular; Sacubitril-valsartan belongs to Cardiovascular.
Why it happens
Inhibition of OATP1B1-mediated hepatic uptake of valsartan by gemfibrozil, raising systemic valsartan levels.
What to do
No routine dose change is needed; monitor blood pressure and serum potassium when starting gemfibrozil.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sacubitril-valsartan
- Aliskiren + Sacubitril-valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
Other interactions of Gemfibrozil
- Daprodustat + Gemfibrozil Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Gemfibrozil + Mavacamten Contraindicated
- Gemfibrozil + Metformin-repaglinide Contraindicated
- Gemfibrozil + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Gemfibrozil + Repaglinide Contraindicated
Frequently asked questions
Can I take Gemfibrozil with Sacubitril-valsartan?
MediHelp rates the interaction as minor. Gemfibrozil and Sacubitril-valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Gemfibrozil inhibits hepatic OATP1B1 uptake, and valsartan is a substrate of this transporter, so valsartan exposure may increase. This could enhance hypotension, hyperkalemia or renal effects, although the clinical significance is probably modest.
How serious is the interaction between Gemfibrozil and Sacubitril-valsartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; monitor blood pressure and serum potassium when starting gemfibrozil.
What other medicines interact with Sacubitril-valsartan?
MediHelp also lists interactions of Sacubitril-valsartan with, for example, Aliskiren, Benazepril, Captopril. The full list is on the Sacubitril-valsartan page.
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