Drug interactions
Gemifloxacin + Histrelin
Severity: Moderate
Gemifloxacin and Histrelin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Histrelin, as a GnRH agonist used for androgen deprivation, may prolong the QT interval, as can gemifloxacin. Combined use may add to the risk of torsades de pointes.
What this interaction means in plain words
Gemifloxacin and Histrelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gemifloxacin belongs to Anti Bacterial; Histrelin belongs to Musculoskeletal.
Why it happens
Additive QT prolongation; androgen deprivation can lengthen QT while gemifloxacin blocks cardiac potassium channels.
What to do
Obtain a baseline ECG and correct electrolyte disturbances. Choose a non-QT-prolonging antibiotic when possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gemifloxacin
- Arsenic trioxide + Gemifloxacin Contraindicated
- Dofetilide + Gemifloxacin Contraindicated
- Gemifloxacin + Ibutilide Contraindicated
- Gemifloxacin + Pimozide Contraindicated
- Gemifloxacin + Thioridazine Contraindicated
- Gemifloxacin + Vandetanib Contraindicated
Other interactions of Histrelin
- Amiodarone + Histrelin Major
- Anagrelide + Histrelin Major
- Histrelin + Thioridazine Major
- Alfuzosin + Histrelin Moderate
- Amisulpride + Histrelin Moderate
- Asenapine + Histrelin Moderate
Frequently asked questions
Can I take Gemifloxacin with Histrelin?
MediHelp rates the interaction as moderate. Gemifloxacin and Histrelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Histrelin, as a GnRH agonist used for androgen deprivation, may prolong the QT interval, as can gemifloxacin. Combined use may add to the risk of torsades de pointes.
How serious is the interaction between Gemifloxacin and Histrelin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct electrolyte disturbances. Choose a non-QT-prolonging antibiotic when possible.
What other medicines interact with Gemifloxacin?
MediHelp also lists interactions of Gemifloxacin with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Gemifloxacin page.
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