Drug interactions
Gemifloxacin + Indomethacin
Severity: Moderate
Gemifloxacin and Indomethacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may increase the CNS stimulating and seizure-provoking effects of fluoroquinolones. The risk is greatest in patients with epilepsy, CNS lesions, or renal impairment.
What this interaction means in plain words
Gemifloxacin and Indomethacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gemifloxacin belongs to Anti Bacterial; Indomethacin belongs to Musculoskeletal.
Why it happens
Fluoroquinolone antagonism of GABA-A receptors may be potentiated by NSAIDs; the mechanism is not fully established.
What to do
Avoid in patients with seizure disorders or lowered seizure threshold; otherwise use the lowest effective doses and counsel the patient to report tremor, agitation or convulsions.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Other interactions of Gemifloxacin
- Arsenic trioxide + Gemifloxacin Contraindicated
- Dofetilide + Gemifloxacin Contraindicated
- Gemifloxacin + Ibutilide Contraindicated
- Gemifloxacin + Pimozide Contraindicated
- Gemifloxacin + Thioridazine Contraindicated
- Gemifloxacin + Vandetanib Contraindicated
Frequently asked questions
Can I take Gemifloxacin with Indomethacin?
MediHelp rates the interaction as moderate. Gemifloxacin and Indomethacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs may increase the CNS stimulating and seizure-provoking effects of fluoroquinolones. The risk is greatest in patients with epilepsy, CNS lesions, or renal impairment.
How serious is the interaction between Gemifloxacin and Indomethacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid in patients with seizure disorders or lowered seizure threshold; otherwise use the lowest effective doses and counsel the patient to report tremor, agitation or convulsions.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.
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